Our Chemical Microtubule Biology laboratory is part of the Department of Bioscience and Bioengineering at the Indian Institute of Technology (IIT) Jodhpur. We are available at lab no. 301 at second floor of chemistry building. Our lab is working at the interface of chemistry and biology which involve peptide synthesis, small molecule synthesis against Alzheimer's disease and Cancer. Our interest also include Chemical Biology (Microtubule Function, ROS & Stem Cells) and designing Biophysical Platform for understanding biological events.
Background:
Surajit was born on December 1977 in Hooghly, West Bengal, India. After completing his Master of Science in Organic Chemistry in 2000, he moved to Syngene International Pvt. Ltd (Biocon Group) and worked as a Scientist till July 2004. Subsequently, he moved to Indian Institute of Technology, Kanpur in August 2004 for his doctoral studies in the group of Prof. Sandeep Verma in the area of Peptide Self-assembly. After completing his Ph. D. thesis in July 2008, he joined as postdoctoral fellow at European Molecular Biology Laboratory, Heidelberg, Germany with Dr. Thomas Surrey, where he worked on organization of microtubule and molecular motor proteins till December 2010. He joined CSIR-Indian Institute of Chemical Biology Kolkata, in 2011, and worked as Principal Scientist (E-II) till 8th July 2019. Subsequently, he has joined as Professor in the Department of Bioscience and Bioengineering at Indian Institute of Technology Jodhpur on 9th July 2019. He is a recipient of BASF and DBT Wellcome Trust Travel grant award, BIOCON Tribute award, EMBL Fellowship, Alexander von Humboldt Fellowship, Ramanujan Fellowship and Indian Peptide Society Young Scientist Award. He is an elected Fellow of Royal Society of Chemistry and West Bengal Academy of Science and Technology. At IIT Jodhpur he is leading Chemical Microtubule Biology Laboratory and his group is currently focusing in the area of Chemical Neuroscience and Chemical Biology.
Dr. Surajit Ghosh, Ph.D., FRSC, FAScT
Professor, Department of Bioscience & Bioengineering
Dean, Research and Development
Indian Institute of Technology Jodhpur
NH 65, Surpura Bypass Road, Karwar, Rajasthan 342037
Phone: +91-291-280-1212 (Office)
Adjunct Faculty-National Institute of Pharmaceutical Education and Research, Kolkata
Associate Editor, RSC Advances
Editorial Board Member-Frontiers in Chemistry (Chemical Biology)
Global Council Member-International Chemical Biology Society
Joint Secretary- Chemical Biology Society of India
Email: sghosh@iitj.ac.in
Member:
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Global Council Member-International Chemical Biology Society
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Communication Committee Member-International Chemical Biology Society
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Member-Asian Chemical Biology Initiative
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Founder Life Member & Joint Secretary-Chemical Biology Society of India
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Life Member-Indian Peptide Society
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Editorial Board Member-Frontiers in Chemistry (Chemical Biology)
Grant Received:
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SERB, Department of Science and Technology, India
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Department of Biotechnology, India
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CSIR-Mission Mode
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India-Japan Cooperative Science Programme (IJCSP)
Selected Publications
36. Prasenjit Mondal, Juhee Khan, Varsha Gupta and Surajit Ghosh.* In silico Approach for Designing Potent Neuroprotective Hexapeptide. ACS Chem Neurosci. 2019, 10, 3018-3030.
35. Surajit Barman, Gaurav Das, Varsha Gupta, Prasenjit Mondal, Krishnangsu Pradhan, Batakrishna Jana, Debmalya Bhunia, Juhee Khan, Deepshikha Mukherjee and Surajit Ghosh.* Dual Arm Nanocapsule Targets Neuropilin-1 Receptor and Microtubule: A Potential Nanomedicine Platform. Mol. Pharmaceutics 2019, 16, 2522-2531.
34. Anindyasundar Adak, Subhajit Ghosh, Varsha Gupta and Surajit Ghosh.* Biocompatible Lipopeptide-Based Antibacterial Hydrogel. Biomacromolecules, 2019, 20 , 5 , 1889-1898.
33. Surajit Barman, Gaurav Das, Prasenjit Mondal, Krishnangsu Pradhan, Batakrishna Jana, Debmalya Bhunia, Abhijit Saha, Chirantan Kar, and Surajit Ghosh.* Tripodal Molecular Propellar Perturbs Microtubule Dynamics: Indole acts as a Blade and Plays Crucial Role in Anticancer Activity. Chem. Commun., 2019, 55, 2356-2359.
32. Surajit Barman, Gaurav Das, Prasenjit Mondal, Krishnangsu Pradhan, Debmalya Bhunia, Juhee Khan, Chirantan Kar, and Surajit Ghosh.* Power of Tyrosine Assembly in Microtubule Stabilization and Neuroprotection Fuelled by Phenol Appendages. ACS Chem Neurosci. 2018, 10, 1506-1516.
31. Gaurav Das, Varsha Gupta and Surajit Ghosh.* Glial-Neuron Transformation by “Chemical Cocktail”. ACS Chem Neurosci. Viewpoint 2019, 10, 42-43.
30. Krishnangsu Pradhan, Gaurav Das, Juhee Khan, Varsha Gupta, Surajit Barman, Anindyasundar Adak, and Surajit Ghosh.* Neuro-Regenerative Choline Functionalized Injectable Graphene Oxide Hydrogel Repairs Focal Brain Injury. ACS Chem Neurosci. 2019, 10, 1535-1543.
29. Krishnangsu Pradhan, Gaurav Das, Varsha Gupta, Prasenjit Mondal, Surajit Barman, Juhee Khan, and Surajit Ghosh.* Discovery of Neuro-regenerative Peptoid from Amphibian Neuropeptide Inhibits Aβ Toxicity and Crossed Blood-Brain Barrier. ACS Chem Neurosci. 2019, 10, 31355-1368.
28. Juhee Khan, Gaurav Das, Varsha Gupta, Saswat Mohapatra, Subhajit Ghosh, and Surajit Ghosh.* Neurosphere Development from Hippocampal and Cortical Embryonic Mixed Primary Neuron Culture: A Potential Platform for Screening Neuro-Chemical Modulator. ACS Chem Neurosci. 2018, 9, 2870–2878.
27. Debmalya Bhunia, Krishnangsu Pradhan, Gaurav Das, Subhajit Ghosh, Prasenjit Mondal, Surajit Ghosh.* Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs. Chem. Commun., 2018, 54, 9309 - 9312.
26. Krishnangsu Pradhan, Gaurav Das, Prasenjit Mondal, Juhee Khan, Surajit Barman, Surajit Ghosh.* Genesis of Neuroprotective Peptoid from Aβ30-34 Inhibits Aβ Aggregation and AChE Activity. ACS Chem Neurosci. 2018, 9, 2929–2940.
25. Prasenjit Mondal, Varsha Gupta, Gaurav Das, Krishnangsu Pradhan, Juhee Khan, Prabir Kumar Gharai and Surajit Ghosh.* Peptide-based Acetylcholinesterase Inhibitor Crosses Blood-Brain Barrier and Promotes Neuroprotection. ACS Chem Neurosci. 2018, 9, 2838-2848.
24. Debmalya Bhunia, Prasenjit Mondal, Gaurav Das, Abhijit Saha, Pallabi Sengupta, Jagannath Jana, Saswat Mohapatra, Subhrangsu Chatterjee, and Surajit Ghosh*, Spatial Position Regulates Power of Tryptophan: Discovery of Major Groove Specific Nuclear Localizing Cell Penetrating Tetrapeptide, J Am Chem Soc., 2018, 140, 1697-1714.
23. Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan and Surajit Ghosh*, Crafting of Neuroprotective Octapeptide from Taxol-Binding Pocket of β-Tubulin, ACS Chem. Neurosci., 2018, 9, 615-625.
22. Anindyasundar Adak, Gaurav Das, Surajit Barman, Saswat Mohapatra, Debmalya Bhunia, Surajit Ghosh.* Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug. ACS Appl Mater Interfaces. 2017, 9, 5067- 5076.
21. Abhijit Saha, Saswat Mohapatra, Gaurav Das, Batakrishna Jana, Subhajit Ghosh, Debmalya Bhunia, and Surajit Ghosh* Cancer cell specific delivery of Photosystem I through integrin targeted liposome shows significant anticancer activity, ACS Appl. Mater. Interfaces, 2017, 9, 176-188.
20. Saswat Mohapatra, Abhijit Saha, Prasenjit Mondal, Batakrishna Jana, Subhajit Ghosh, Atanu Biswas and Surajit Ghosh*. Synergistic anticancer effect of peptide-docetaxel nano-assembly targeted to tubulin: Towards development of dual warhead containing nanomedicine. Adv Healthcare Mater., 2017, 6, 1600718 (Accepted as cover page).
19. Subhajit Ghosh, Saswat Mohapatra, Anisha Thomas, Debmalya Bhunia, Abhijit Saha, Gaurav Das, Batakrishna Jana and Surajit Ghosh*, Apoferritin-nanocage delivers combination of microtubule and nucleus targeting anticancer drugs. ACS Appl. Mater. Interfaces, 2016, 8, 30824–30832.
18. Debmalya Bhunia#, Saswat Mohapatra#, Prashant Kurkute, Subhajit Ghosh, Batakrishna Jana, Prasenjit Mondal, Abhijit Saha, Gaurav Das and Surajit Ghosh*. Novel Tubulin-targeted Cell Penetrating Antimitotic Octapeptide. Chem. Commun., 2016, 52, 12657-12660.
17. Saswat Mohapatra#, Soumen Nandi#, Rajdeep Chowdhury#, Gaurav Das, Surajit Ghosh* and Kankan Bhattacharyya* . Spectral Mapping of 3D Multi-cellular Tumor Spheroid: Time-resolved Confocal Microscopy. Phys Chem Chem Phys., 2016,18,18381 - 18390.
16. Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Surajit Barman, Krishnangsu Pradhan, Abhijit Saha and Surajit Ghosh*. α-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell. ACS Appl. Mater. Interfaces, 2016, 8 (22),13793–13803.
15. Anindyasundar Adak#, Saswat Mohapatra#, Prasenjit Mondal, Batakrishna Jana and Surajit Ghosh.* Design of novel microtubule targeted peptide vesicle for delivering different anticancer drugs. Chem. Commun., 2016, 52, 7549-7552 (Accepeted as Cover page)
14. Atanu Biswas, Prashant Kurkute, Suraiya Saleem, Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Anindyasundar Adak, Subhajit Ghosh, Abhijit Saha, Debmalya Bhunia, Subhash Chandra Biswas, and Surajit Ghosh*. Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chem. Neurosci., 2015, 6, 1309-1316. (Accepted as cover page)
13. Batakrishna Jana, Jayita Sarkar, Prasenjit Mondal, Surajit Barman, Saswat Mohapatra, Debmalya Bhunia, Krishnangsu Pradhan, Abhijit Saha, Anindyasundar Adak, Subhajit Ghosh and Surajit Ghosh*. A short GC rich DNA derived from microbial origin targets tubulin/microtubule and induces apoptotic death of cancer cell. Chem.Commun. 2015, 51, 12024-12027.
12. Jyothi B Nair#, Saswat Mohapatra#, Surajit Ghosh*, Kaustabh K Maiti*. Novel Lysosome Targeted Molecular Transporter Built On Guanidinium-Poly-(propylene imine) Hybrid Dendron for Efficient Delivery of Doxorubicin into Cancer Cells. Chem.Commun. 2015, 51, 2403-2406.
11. Abhijit Saha, Saswat Mohapatra, Prashant Kurkute, Batakrishna Jana, Prasenjit Mondal, Debmalya Bhunia, Subhajit Ghosh and Surajit Ghosh.* Interaction of Aβ peptide with tubulin causes inhibition of tubulin polymerization and apoptotic death of cancer cells. Chem. Commun. 2015, 51, 2249-2252. (Accepted as cover page)
10. Batakrishna Jana, Atanu Biswas, Saswat Mohapatra, Abhijit Saha and Surajit Ghosh.* Single functionalized graphene oxide reconstitutes kinesin mediated intracellular cargo transport, delivers multiple cytoskeleton proteins and therapeutic molecule into the cell. Chem. Commun. 2014, 50, 11595-11598.
9. Atanu Biswas, Prashant Kurkute, Batakrishna Jana, Aparna Laskar and Surajit Ghosh.* Amyloid inhibitor octapeptide forms amyloid type fibrous aggregate and affect in microtubule motility. Chem. Commun., 2014, 50, 2604-7.
8. Atanu Biswas#, Abhijit Saha#, Dhruba Ghosh, Batakrishna Jana and Surajit Ghosh.* Co- and distinct existence of Tris-NTA and biotin functionalities on individual and adjacent micropatterned surfaces generated by photo-destruction. Soft Matter, 2014, 10, 2341-45. (Accepted as cover page)
7. Abhijit Saha, Goutam Mondal, Atanu Biswas, Indrani Chakraborty, Batakrishna Jana and Surajit Ghosh.* In vitro reconstitution of a cellular like environment using liposome for amyloid beta peptide aggregation and its propagation. Chem. Commun., 2013, 49, 6119-6121. (Accepted as cover page).
6. Surajit Ghosh, Christian Hentrich, and Thomas Surrey.* Micropattern-Controlled Local Microtubule Nucleation, Transport, and Mesoscale Organization. ACS Chem. Biol., 2013, 8, 673-678.
5. Maniraj Bhagawati,# Surajit Ghosh,# Annett Reichel, Klaus Froehner, Thomas Surrey, Jacob Piehler.* Organization of motor proteins into functional micropatterns fabricated by a photo-induced Fenton reaction. Angew. Chem. Int. Ed. 2009, 48, 9188-91918. Accepted as Hot Paper.
4. Surajit Ghosh, Arindam Mukherjee, Peter. J. Sadler.* Sandeep Verma.* Periodic Iron Nanomineralization in Human Serum Transferrin Fibrils. Angew. Chem. Int. Ed. 2008, 47, 2217-2221. (Accepted as Very Important Paper, Cover Page, Highlighted by: Nature India; C & E News; Angew. Chem., EurekAlert).
3. Surajit Ghosh, Sandeep Verma.* Templated growth of hybrid structures at peptide-peptide interface. Chem. Eur. J. 2008, 14, 1415-14194.
2. Surajit Ghosh, SukhmaniKaur Singh, Sandeep Verma.* Self-assembly and potassium ion triggered disruption of peptide-based soft structures. Chem. Commun. 2007, 22, 2296-2298.
1. Surajit Ghosh, Meital Reches, Ehud Gazit,* Sandeep Verma.* Bioinspired design of nanocages by self-assembling triskelion peptide elements. Angew. Chem. Int. Ed. 2007, 46, 2002-2004 (Accepted as cover page).
*: Corresponding Author; #: Equal contribution
Positions Held :
9th July 2019-till date: Professor, Indian Institute of Technology Jodhpur
March 2018 Visiting Scientist, ISIR, Osaka University, Japan
September 2015- till date : Associate Editor (Chemical Biology), Royal Society of Chemistry Advances
April 2014- 8th July 2019: Principal Scientist at CSIR-IICB, Kolkata & Associate Professor, AcSIR, India
2011- 2015: Ramanujan Fellow
October 2012: Visiting Scientist, Cancer Research Institute London, UK
August-October 2012: Alexander von Humboldt Fellow in Rudolph Virchow Centre
University of Wurzburg, Germany
January 2010-December 2010: Alexander von Humboldt Fellow, Cell Biology and Biophysics Unit European Molecular Biology Laboratory, Heidelberg, Germany
July 2008-December 2009: EMBL Postdoctoral Fellow, Cell Biology and Biophysics Unit European Molecular Biology Laboratory, Heidelberg, Germany
January2001−July2004: Scientist, BIOCON, 20th KM, Hosur Road Electronics, Bangalore, India
Awards/Recognition/ & Honors:
2020 CDRI Award 2020 for Excellence in Drug Research in the chemical sciences category
2019 Journal of American Chemical Society Young Investigators Virtual Issue
2018 Member Asian Chemical Biology Initiative
2018 Elected Fellow of the West Bengal Academy of Science and Technology
2018 Prof. Asima Chatterjee Young Scientist Award
2017 Syamasri Gupta Memorial Young Scientist Award from Indian Society for Surface Science & Technology
2017 Travel Grant by International Chemical Biology Society for Invited Lecture at Shanghai, China
2017 Young Scientist Award from Indian Peptide Society
2016 Fellow of Royal Society of Chemistry (FRSC), UK
2015 Associate Editor, RSC Advances
2010 Ramanujan Fellow (2011-2015)
2010 Travel grant by DBT/ Wellcome Trust for attending “EMBO Global Exchange & the Wellcome Trust/DBT India Alliance meeting” at Barcelona
2009 Alexander Von Humboldt Fellow
2008 EMBL Fellow
2007 Travel Grant by BASF Company for attending in International Symposium “BASF Conference on Nanomaterials” in Singapore.
2002 Biocon Tribute award for important contribution (Biocon India Group)
Invited Presentation:
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Invited Speaker at the 2nd National Organic Symposium Trust (NOST) held at Jaipur, India, October 11-14, 2006.
Title: “Phased Peptide Fiber Growth in Prion Octarepeat Mutant: Aggregation and Disaggregation studies”
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Invited Speaker at Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Germany, May 15, 2009.
Title: "Biomimetic Assembly of IntracelluarMotility with Minimum Components"
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Invited Speaker in Colloquium Lecture at Bose Institute, Kolkata, India, June 24, 2010.
Title: "Biomimetic Assembly of Intracellular Motility with Minimum Components"
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Invited Speaker at the Indian Peptide Symposium, Kolkata, February 21-22, 2013
Title: "Reconstitution of prion propagation with minimum components inside the liposome"
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Invited Speaker at 4th Asia Specific Peptide Symposium (APIPS) at Osaka, Japan, November 6, 2013.
Title: "In vitro reconstitution of a cellular like environment using liposome for Aβ peptide aggregation, its propagation, peptide-lipid interaction and drug screening "
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Invited Speaker at 5th Asian Conference on Colloid and Interface Science (ACCIS 2013) at the University of North Bengal, Darjeeling, India, November 20-23, 2013.
Title: "Biomolecular Assembly in Solution and Interface"
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Invited Speaker at 2nd Ramanujan Meeting at IISER Pune, December 13-14, 2013.
Title: "Biomolecular Assembly in Solution and Interface"
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Invited Speaker in Colloquium Lecture at CSIR-IICB, Kolkata, India, January 20, 2014.
Title: "Development of Various Platforms for Reconstitution of Biological Events"
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Invited Speaker in 1st KANSAI Nanoscience and Nanotechnology International Symposium at OSAKA, JAPAN, February 3, 2014.
Title: "Surface Modification and Patterning for Reconstitution of Biological Events and Delivering Therapeutic Molecules"
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Invited Speaker in Humboldt Kolleg at IISC Bangalore, September 4, 2014.
Title: "Interaction between Aβ and Aβ-inhibitor peptide with tubulin/microtubule"
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Invited Speaker in International Symposium on Advances in Spectroscopy and Ultrafast Dynamics
at ACS, Kolkata, December 12-14, 2014.
Title: "Functionalized graphene oxide walks along the microtubule and delivers therapeutic molecules into the cell"
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Invited Speaker in International Symposium on Bioorganic Chemistry (ISBOC-10) at
IISER Pune, January 12, 2015.
Title: "Interaction of Aβ peptide with tubulin/microtubule causes inhibition of tubulin polymerization and apoptotic death of cancer cells "
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Invited Speaker at Ramanujan Fellowship Review Meeting on 16th March 2015 at IIT Bombay.
Title: "Biomolecular assembly in solution and interface"
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Invited Speaker at refresher course on 30th March 2015, Venue: Calcutta University (Rajabazar Science College-Campus).
Title: "Recently developed chemical tools for understanding/perturbing various biological events"
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Invited Speaker at CSIR-IICB Research festival 5th June 2015
Title: "A short GC rich DNA derived from microbial origin targets tubulin/microtubule and induces apoptotic death of cancer cell"
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Invited Speaker in 4th International Conference on Advanced Nanomaterials and Nanotechnology (ICANN2015), on 08-11 December 2015 at the Indian Institute of Technology Guwahati.
Title: "Microtubule targeted chemically functionalized graphene oxide micro/nano particle"
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Invited Speaker in 17th All India Congress of Cytology and Genetics (22-24 December 2015). Title: "Microtubule targeted chemically functionalized graphene oxide micro/nanoparticle"
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Invited Speaker in Sixth International Conference on Metals in Genetics, Chemical Biology and Therapeutics (ICMG-2016), from 17-21st February 2016 at IISc Bangalore
Title: "Microtubule targeted neuroprotective peptide"
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Invited Speaker at the National level Symposium Facets of Chemistry in Biology-2016 at St. Xavier’s College, Kolkata on 22- 23 February 2016.
Title: "Chemical tools for understanding/perturbing various biological events"
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Invited Speaker in the International symposium on Chemical Biology and Drug Discovery at Hotel Taj, Kolkata on 1-3 March 2016.
Title: "Development of novel delivery vehicles for targeted delivery of docetaxel "
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Invited Speaker in the International symposium NANOBIOCON at Science City, Kolkata on 3-4 Oct 2016.
Title: "Microtubule targeted chemically functionalized graphene oxide micro/nano particle"
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Invited Speaker in the TEQIP II sponsored workshop on “Fundamentals and Applications in Biomolecular Spectroscopy ” at NIT Patna during 25th-26th October, 2016
Title: "Understanding Dynamics of Biological Systems using Fluorescence Spectroscopy and Microscopy"
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Invited Speaker in the Indo-German meeting in November 10-13, 2016 at Khajuraho
Title: "Cancer Cell Specific Delivery of Docetaxel: Towards Development of Nanomedicine"
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Invited Speaker in the "The 20th ISIR International Symposium on Molecular Technology Frontiers towards IoT World, 12-13th in December, 2016, in Osaka, Japan Title: "Cancer Cell Specific Delivery of Docetaxel: Towards Development of Nanomedicine"
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Invited Speaker in the 5th Symposium on the Advances in Bioinorganic Chemistry, January 7-11, 2017 in Kolkata, India
Title: "Purine Based Metal Carbene Complexes for Inhibition of Tubulin Polymerization"
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Invited Speaker at IIT Patna on 1st February 2017
Title: "Microtubule targeted neuroprotective peptide"
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Invited Speaker in the TEQIP II sponsored Short Term Course on “Strengthening of Institute-Industry Interaction” at NIT Patna 2nd February, 2017
Title: "Development of Cancer Cell Specific Docetaxel Nanoformulation"
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Invited Speaker in NDD 2017: International Conference on “Neurodegenerative Disorders: Current and Future Perspective", February 10-12, 2017 in Kolkata, India
Title: "Microtubule targeted neuroprotective peptide"
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Invited Speaker in a Summer School in Chemical Sciences in the Rajabazar Science College Campus on 6th February 2017
Title: "Development of Cancer Cell Specific Docetaxel Nanoformulation"
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Invited Speaker in Indian Peptide Symposium on February 23, 2017, at Homi Bhaba Centre, Mumbai, India (Young Scientist Award Talk)
Title: "Microtubule targeted neuroprotective peptide"
Academic Details:
M.Sc: Calcutta University (1998-2000)
Ph.D: Indian Institute of Technology Kanpur (2004-2008)
Post.Doc: European Molecular Biology Laboratory, Heidelberg, Germany (2008-2010)
